Construction of enantiopure pyrrolidine ring system via asymmetric [3+2]-cycloaddition of azomethine ylides
Article Abstract:
The reaction of azomethine ylides (AMY) with alkenes is presented as a powerful method for the syntheses of substituted and stereoisomerically pure pyrrolidines. The synthesis of highly substituted pyrrolidines ins in optically pure form via asymmetric [3+2]-cycloaddition of azomethine ylides, which allows simultaneous construction of up to four stereocenters is increasingly becoming an important strategy, in view of their forming integral part of numerous biologically active alkaloids and pharmaceuticals.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
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Macrolactonizations in the total synthesis of natural products
Article Abstract:
Overview of all the macrolactonization reactions involving activation of any one extremity of seco-acids in the synthesis of natural products is presented. Difficulty posed in direct cyclization owing to the entropic and enthalpic factors has inspired solutions like activation of acids and activation of alcohols to obtain macrocyclic lactones.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
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Alkylidenecarbenes, alkylidenecarbenoids, dagger and competing species: which is responsible for vinylic nucleophilic substitution, [1 plus 2] cycloadditions, 1,5-CH insertion and the Fritsch-Buttenberg-wiechell rearrangement?
Article Abstract:
The ability to perform 1,5-CH insertion reactions [1 plus 2] cycloadditions, and the Fritsch-Buttenberg-wiechell rearrangements seem to be common for alkylidenecarbienoids R (super 1) R (super 2) C=CMX and the short-lived alkylidenecarbenes R (super 1) R (super 2) C=C.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2004
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